The stomach may trap drugs that are ____________, leading to drug accumulation.

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Study for the Pharmaceutics Xenobiotics Across Bio Membrane Test. Use flashcards and multiple-choice questions with detailed explanations. Master critical concepts and excel in your exam!

Multiple Choice

The stomach may trap drugs that are ____________, leading to drug accumulation.

Explanation:
Ion trapping across pH gradients governs where a drug accumulates. The stomach is highly acidic, so weak bases pick up a proton and become positively charged. This ionized form crosses membranes poorly, so it tends to stay in the stomach rather than move into the blood, leading to accumulation there. Weak acids in the same environment become non-ionized and can cross membranes more easily, so they are not trapped in the stomach. Hence, drugs that are weak bases undergo ion trapping in the stomach, causing accumulation.

Ion trapping across pH gradients governs where a drug accumulates. The stomach is highly acidic, so weak bases pick up a proton and become positively charged. This ionized form crosses membranes poorly, so it tends to stay in the stomach rather than move into the blood, leading to accumulation there. Weak acids in the same environment become non-ionized and can cross membranes more easily, so they are not trapped in the stomach. Hence, drugs that are weak bases undergo ion trapping in the stomach, causing accumulation.

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